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KMID : 0356420060240030156
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Journal of Korean Andrology
2006 Volume.24 No. 3 p.156 ~ p.161
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Effects of Testosterone on the Expression of Transforming Growth Factor (TGF)-?1 in Rat Penile Corpus Cavernosum
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Jung Seung-Il
Park Kwang-Sung
Lee Mi-Na
Ahn Kyu-Youn
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Abstract
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Purpose: The aim of this study was to elucidate the effect of testosterone on the expression of transforming growth factor (TGF)-?1 in rat penile corpus cavernosum.
Materials and Methods: Male Sprague Dawley rats (n=60) were divided into 3 groups: control, castration, and testosterone replacement after castration. Testosterone was administered for7 days at week 1 and week 2 after castration. The intracavernosal pressure/systemic blood pressure was recorded after pelvic nerve stimulation. Expression of TGF-?1 was determined by immunoblotting and immunohistochemistry.
Results: At week 1 and 2 after castration, the intracavernosal pressure/systemicblood pressure was significantly decreased in the castration group (31.3±15.7%, 18.6±4.6%) compared to the control group (58.0±11.4%, 58.9±8.2%) and testosterone replacement group (50.6±14.5%, 49.1±19.4%)(p＜0.05). The expression of TGF-?1 was increased at both 1 and 2 weeks of castration compared to the control group, and was down-regulated with testosterone replacement.
Conclusions: These results suggest that the testosterone maintains erectile function and regulates the expression of TGF-?1 in the rat penile corpus cavernosum.
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KEYWORD
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Erectile dysfunction, Testosterone, TGF-?1
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